ImaGene CGH

Powerful DNA Copy Number Analysis

ImaGene aCGH Module is the leading edge technology in microarray-based Comparative Genomic Hybridization (CGH) analysis developed to provide researchers a powerful tool to assess DNA copy number variations. ImaGene aCGH Module is fully integrated into ImaGene 8.0, presented as an additional analysis capability of this pioneering platform for genomic research with aCGH specific analysis and visualization.

ImaGene CGH Module With ImaGene aCGH Module, you have all the features of ImaGene 8.0 delivering the highest quality data and the most powerful automation to quantify, normalize and analyze your experiments. And with this automation, you reduce the risks of operator error, making your data more reliable and your experiments reproducible. The aCGH Module is presented within ImaGene 8.0's elegant user interface with fluid navigation that makes you productive in no time at all. In addition, the interactive integrated visualization tools enable you to quickly drill-down from a chromosomal region to a single spot on the array to ensure correct interpretation of results.

ImaGene Testimonial

Features in Finer Focus

ImaGene aCGH Module allows you to get a fine grain view of your sample's chromosomal data with advanced analytical features that will make you confident in your data and its reproducibility.

  • One-Button Quantification, Normalization and Analysis - the high degree of automation reduces operator error to ensure high quality and reliable data, and reproducible experiments.
  • Change Point Detection Algorithm - ImaGene aCGH Module's statistical-based and customizable Gain / Loss Call Algorithm offers the best balance of speed and accuracy of results and puts you in control with user-defined algorithm parameters to filter out the noise from your experiments detecting chromosomal deletions and amplifications to your threshold requirements.
  • Integrated & Interactive Chromosome Plots - elegant navigation provides the ability to visualize spot images, see corresponding data tables and analysis results down to individual spot deletions or amplifications, while viewing chromosome location. A special zoom function provides focus along a specific section of an individual chromosome. A variety of plot types for display or export as graphics files:
    ImaGene CGH ModuleSummary Plot
    Shows a complete summary of the data highlighting areas of gain / loss by coloring the ideograms as well as showing the raw values for all the spots.
    ImaGene CGH ModuleOverview Plot
    Provides an overview of the whole genome indicating areas of gain (green) and loss (red). Double bars indicate high gain/loss.
    ImaGene CGH ModuleWhole Genome Plot
    Shows the raw data for the whole genome arranging each chromosome end-to-end on the x-axis.
    ImaGene CGH ModuleChromosome View
    Allows the user to look at a single chromosome at a time and see the spots (circles), the call algorithm results (magenta line) and moving average (yellow line) all at the same time.
    CGH Box PlotBox-plot
    ImaGene CGH ReportCGH report output file
       
  • Point and Click Analysis - with just a click of your mouse you can move from chromosome to chromosome or from spot to spot within a chromosome for rapid analysis and visual QC of your experiment results.
  • Interconnection with Web Resources - direct integration with UCSC and Ensembl web-based resources to extend your research capability to the global research community.
  • Fully integrated into ImaGene 8.0 - easy to use, simply load the file and go to work - no separate software, and no unique data importing requirements.

    • ImaGene 8.0 - Features You Can Rely On

    With ImaGene aCGH you can rely on all the proven capabilities of the fully integrated ImaGene 8.0, including these core features.

    • Automated spot finding and grid placement
    • Spot & array-level automated quality control
    • Patented automated segmentation
    • One-button batch processing
    • High quantification accuracy
    • Intuitive interface design and navigation
    • Integrated and interactive analysis results
    • Diverse system compatibility

    Get Started Today

    Contact BioDiscovery today for more information about the ImaGene aCGH module or ImaGene 8.0. Visit our web site at www.biodiscovery.com, email us at info@biodiscovery.com or call 310-414-8100.

    ImaGene aCGH Module is a research tool; not reviewed or cleared by the U.S. FDA for use in human diagnostics.